We recently examined potential relationship between tau protein uptake in medial temporal lobe (MTL) and volumetric measures of MTL subregions in a small dataset of Alzheimer’s disease patients. Since tau protein accumulates in MTL in a characteristic spatiotempoal pattern as … Continue reading
Daniel Adler’s MICCAI 2016 paper “Probabilistic atlas of the human hippocampus combining ex vivo MRI and histology” describes substantial progress on building a comprehensive atlas of the human hippocampus that combines ultra-high resolution ex vivo MRI and serial histological imaging. … Continue reading
Neuroscientific investigations seek to reveal how neural systems perform complex functions, how those systems and functions are altered in disease states, and how therapeutic interventions can be used to redirect these alterations. In essence, all three lines of investigation seek … Continue reading
We have recently updated ANTs to perform processing of perfusion ASL images. The pipeline is designed to be consistent with the antsCorticalThickness pipeline for computing cortical thickness and incorporates state-of-the-art methods for correcting for motion and other confounds. Learn more … Continue reading
The complex and high-dimensional nature of medical images makes them difficult to incorporate into traditional linear model-based statistical analysis. One way of simplifying analysis of medical images is to use a dimensionality reduction technique. We designed a dimensionality reduction technique … Continue reading
Our paper looking at dissociable functional networks of anterior and posterior MTL regions in older healthy controls and MCI patients just got accepted for publication in Neurobiology of Aging. We labeled MTL subregions in high-resolution T2-MRI using our automated MTL subregion … Continue reading
We just found out that our R03 grant application for high-resolution BOLD fMRI at 7T has been recommended for funding. We have been anxiously waiting for the funding decision which was delayed by the government shutdown last year. Better late than … Continue reading
There is a ton of work looking at BOLD functional connectivity (FC) in Alzheimer’s Disease, and one consensus that has emerged is that this is a disconnection syndrome, with most studies finding weaker connectivity within the default mode network (DMN), … Continue reading
Abstract: Responses to acute stressors are determined in part by stress history. For example, a history of chronic stress results in facilitated responses to a novel stressor and this facilitation is considered to be adaptive. We previously demonstrated that repeated … Continue reading