Multi-Template Analysis of Human Perirhinal Cortex in Brain MRI: Explicitly Accounting for Anatomical Variability

The human perirhinal cortex (PRC) plays critical roles in episodic and semantic memory and visual perception. The PRC consists of Brodmann areas 35 and 36 (BA35, BA36). In Alzheimer’s disease (AD), BA35 is the first cortical site affected by neurofibrillary … Continue reading

Relating brain anatomy and cognitive ability using a multivariate multimodal framework

Linking structural neuroimaging data from multiple modalities to cognitive performance is an important challenge for cognitive neuroscience. In this study we examined the relationship between verbal fluency performance and neuroanatomy in 54 patients with frontotemporal degeneration (FTD) and 15 age-matched … Continue reading

Regional Thickness Measurement of Extra-hippocampal Medial Temporal Lobe Structures

Extra-hippocampal medial temporal lobe (ehMTL) structures, which consists of entorhinal (ERC) and perirhinal (PRC) cortices, receives increasing attention because they are amongst the earliest sites affected by Alzheimer`s Disease (AD) pathology and due to their important and complex role in episodic … Continue reading

Sparse Dimensionality Reduction for Medical Imaging

The complex and high-dimensional nature of medical images makes them difficult to incorporate into traditional linear model-based statistical analysis.  One way of simplifying analysis of medical images is to use a dimensionality reduction technique.  We designed a dimensionality reduction technique … Continue reading

Associations between children’s socioeconomic status and prefrontal cortical thickness

Childhood socioeconomic status (SES) predicts executive function performance and measures of prefrontal cortical function, but little is known about its anatomical correlates. Structural MRI and demographic data from a sample of 283 healthy children from the NIH MRI Study of … Continue reading