Multi-Template Analysis of Human Perirhinal Cortex in Brain MRI: Explicitly Accounting for Anatomical Variability


The human perirhinal cortex (PRC) plays critical roles in episodic and semantic memory and visual perception. The PRC consists of Brodmann areas 35 and 36 (BA35, BA36). In Alzheimer’s disease (AD), BA35 is the first cortical site affected by neurofibrillary … Continue reading

Important milestone for the Penn ex vivo atlas of the human hippocampus formation

Labeling of hippocampal subfields in an ex vivo MRI scan on the basis of micro-anatomical features derived from histology.  Boundaries drawn in histology space are mapped into the MRI space after histology-MRI registration, and volumetric labeling of hippocampal subfields is performed in MRI space.

Daniel Adler’s MICCAI 2016 paper “Probabilistic atlas of the human hippocampus combining ex vivo MRI and histology” describes substantial progress on building a comprehensive atlas of the human hippocampus that combines ultra-high resolution ex vivo MRI and serial histological imaging. … Continue reading