Tau-PET imaging and subregional atrophy in medial temporal lobe

We recently examined potential relationship between tau protein uptake in medial temporal lobe (MTL) and volumetric measures of MTL subregions in a small dataset of Alzheimer’s disease patients. Since tau protein accumulates in MTL in a characteristic spatiotempoal pattern as … Continue reading

Medial temporal lobe subregional morphometry using high resolution MRI in Alzheimer’s Disease

Figure2_rev

Recently published paper by Wolk et al. in Neurobiology of Aging examines the involvement of hippocampal subfields and medial temporal lobe (MTL) cortical subregions in different stages of Alzheimer’s disease (AD). The study used high-resolution T2-weighted MRI scans of the … Continue reading

Important milestone for the Penn ex vivo atlas of the human hippocampus formation

Labeling of hippocampal subfields in an ex vivo MRI scan on the basis of micro-anatomical features derived from histology.  Boundaries drawn in histology space are mapped into the MRI space after histology-MRI registration, and volumetric labeling of hippocampal subfields is performed in MRI space.

Daniel Adler’s MICCAI 2016 paper “Probabilistic atlas of the human hippocampus combining ex vivo MRI and histology” describes substantial progress on building a comprehensive atlas of the human hippocampus that combines ultra-high resolution ex vivo MRI and serial histological imaging. … Continue reading

Regional Thickness Measurement of Extra-hippocampal Medial Temporal Lobe Structures

Extra-hippocampal medial temporal lobe (ehMTL) structures, which consists of entorhinal (ERC) and perirhinal (PRC) cortices, receives increasing attention because they are amongst the earliest sites affected by Alzheimer`s Disease (AD) pathology and due to their important and complex role in episodic … Continue reading