Laura Wisse


Research Overview

My main interests are imaging of the medial temporal lobe in aging and diseases such as Alzheimer disease and Major Depressive Disorder. I am involved in the development of new tools for assessing medial temporal lobe structures, but I am also interested in investigating how these medial temporal lobe structures relate to aging, disease and cognitive functions, such as memory.
I am part of the Hippocampus Gang, led by Paul Yushkevich and David Wolk.


2010: MSc in Psychology at Leiden University, The Netherlands
2014: MSc in Epidemiology at Utrecht University, The Netherlands
2014: PhD in Neuroscience at Utrecht University, The Netherlands


  • Brightfocus Postdoctoral Fellowship Award in Alzheimer’s Disease Research
    The temporal lobe in preclinical AD and aging.
    Role: PI
  • Joint Programme for Neurodegenerative Diseases Award
    Harmonized Hippocampal Subfield Segmentation Working Group
    Role: Co-Investigator
  • Institute for Translational Medicine and Therapeutics Translational Biomedical Imaging Center Grant
    Quantitative analysis of the e ffects of neuropsychiatric disease on the subregions of the amygdala.
    Role: Co-Investigator

Scholarships and awards

  • 2012-2017: Eleven travel fellowships awarded by the Internationale Stichting Alzheimer Onderzoek, Alzheimer Nederland, the Alzheimer’s Association International Conference, the Society for Neuroscience and the Biomedical Postdoctoral Program travel award to attend international conferences.
  • 2013: Award for best poster presentation at the 4th PhD Epidemiology Seminar.
  • 2008: Van de Geer Prize for the best MSc-thesis of Psychology at Leiden University 07-08.


  1. Blom, K., Koek, H.L., Van der Graaf, Y., Zwartbol, M., Wisse, L.E.M., Hendrikse, J., Biessels, G.J., Geerlings, M.I., on behalf of the SMART Study Group (2018). Hippocampal sulcal cavities: prevalence, risk factors, and association with cognitive performance. The SMART-Medea and PREDICT-MR study. Brain Imaging and Behaviour, epub ahead of print.
  2. Wisse, L.E.M., Adler, D.H., Ittyerah, R., Pluta, J.B., Ding, S.-L., Xie, L., Wang, J., Kadivar, S., Robinson, J.L., Schuck, T., Trojanowski, J.W., Grossman, M., Detre, J.A., Elliott, M.A., Toledo, J.B., Liu, W., Pickup, S., Miller, M.I., Das, S.R., Wolk, D.A., Yushkevich, P.A. (2018). Characterizing the human hippocampus in aging and Alzheimer’s disease using a computational atlas derived from ex vivo MRI and histology. Proceedings of the National Academy of Sciences, 115 (16), 4252-4257.
  3. Wisse, L.E.M., Das, S.R., Davatzikos, C., Dickerson, B.C., Xie, S.X., Yushkevich, P.A., Wolk, D.A., for the Alzheimer’s Disease NeuroImaging Initiative (2018). Defining SNAP by cross-sectional and longitudinal definitions of neurodegeneration. NeuroImage Clinical, 18, 407-412.
  4. Das, S.R., Xie, L., Wisse, L.E.M., Ittyerah, R., Tustison, N.J., Dickerson, B.C., Yushkevich, P.A., Wolk, D.A., for the Alzheimer’s Disease Neuroimaging Initiative (2018). Longitudinal structural atrophy correlates with AV-1451 tau uptake in amyloid-positive individuals. Neurobiology of Aging, 66, 49-58.
  5. Xie, L., Shinohara, R.S., Ittyerah, R., Kuijf, H.J., Pluta, J.B., Blom, K., Kooistra, M., Reijmer, Y.D., Koek, H.L., Zwanenburg, J.J.M., Wang, H., Luijten, P.R., Geerlings, M.I., Das, S.R., Biessels, G.J., Wolk, D.A., Yushkevich, P.A., Wisse, L.E.M. (2018). Automated multi-atlas segmentation of hippocampal and extrahippocampal subregions in Alzheimer’s disease at 3T and 7T: what atlas composition works best? Journal of Alzheimer’s disease, 63 (1), 217-225.
  6. Xie, L., Das, S.R., Wisse, L.E.M., Ittyerah, R, Yushkevich, P.A., Wolk, D.A., for the Alzheimer’s Disease Neuroimaging Initiative (2017). Early tau burden correlates with higher rate of atrophy in transentorhinal cortex. Journal of Alzheimer’s disease, 62 (1), 85-92.
  7. Shah, P., Bassett, D.S., Wisse, L.E.M., Detre, J.A., Stein, J.M., Yushkevich, P.A., Shinohara, R.T., Pluta, J.B., Valenciano, E., Daffner, M., Wolk, D.A., Elliott, M.A., Litt, B., Davis, K.A., Das, S.R. (2017). Mapping the structural and functional network architecture of the medial temporal lobe using 7T MRI. Human Brain Mapping, 39 (2), 851-865.
  8. Berron, D., Vieweg, P., Hochkeppler, A., Pluta, J.B., Ding, S.-L., Maass, A., Luther, A., Xie, L., Das, S.R., Wolk, D.A., Wolbers, T., Yushkevich, P.A., Duzel, E., Wisse, L.E.M. (2017). A protocol for manual segmentation of medial temporal lobe subregions in 7 tesla MRI. NeuroImage Clinical, 15, 466-482.
  9. Lawson, G.M., Camins, J.S., Wisse, L.E.M., Wu, J., Duda, J.T., Cook, P.A., Gee, J.C., Farah, M.J. (2017). Childhood socioeconomic status and childhood maltreatment: Distinct associations with brain structure. Plos One, 12 (4), e0175690.
  10. Wisse, L.E.M., Daugherty, A.M., Olsen, R.K., Berron, D., Carr, V.A., Stark, C.E.L., Amaral, R.S.C., Amunts, K., Augustinack, J.C., Bender, A.R., Bernstein, J.D., Boccardi, M., Bocchetta, M., Burggren, A., Chakravarty, M.M., Chupin, M., Ekstrom, A., de Flores, R., Insausti, R., Kanel, P., Kedo, O., Kennedy, K.M., Kerchner, G.A., LaRocque, K.F., Liu, X., Maass, A., Malykhin, N., Mueller, S.G., Ofen, N., Palombo, D.J., Parekh, M.B., Pluta, J.B., Pruessner, J.C., Raz, N., Rodrigue, K.M., Schoemaker, D., Shafer, A.T., Steve, T.A., Suthana, N., Wang, L., Winterburn, J.L., Yassa, M.A., Yushkevich, P.A., la Joie, R. for the Hippocampal Subfields Group (2016). A harmonized segmentation protocol for hippocampal and parahippocampal subregions: why do we need one and what are the key goals? Hippocampus, 27 (1), 3-11.
  11. Xie, L., Pluta, J.B., Das, S.R., Wisse, L.E.M., Wang, H., Mancuso, L., Kliot, D., Avants, B.B., Ding, S.L., Manjon, J.V., Wolk, D.A., Yushkevich, P.A. (2016). Multi-Template analysis of human perirhinal cortex in brain MRI: explicitly accounting for anatomical variability. NeuroImage, 1 (144), 183-202.
  12. Wisse, L.E.M., Adler, D.H., Ittyerah, R., Pluta, J. B., Robinson, J.L., Schuck, T., Trojanowski, J.Q., Grossman, M., Detre, J.A., Elliott, M.A., Toledo, J.B., Liu, W., Pickup, S., Das, S.R., Wolk, D.A., Yushkevich, P.A. (2016). Comparison of in vivo and ex vivo MRI of the human hippocampal formation in the same subjects. Cerebral Cortex, 27 (11), 5185-5196.
  13. Bouvy, W.H., Zwanenburg, J.J.M., Reinink, R., Wisse, L.E.M., Luijten, P.R., Kappelle, L.J., Geerlings, M.I., Biessels, G.J. (2016). Perivascular spaces on 7 Tesla brain MRI are related to markers of small vessels disease but not to age or cardiovascular risk factors. Journal of Cerebral Blood Flow and Metabolism, 36 (10), 1708-1717.
  14. Wisse, L.E.M., Kuijf, H.J., Honingh, A.M., Wang, H., Pluta, J.B., Das, S.R., Wolk, D.A., Zwanenburg, J.J.M., Yushkevich, P.A., Geerlings, M.I. (2016). Automated hippocampal subfield segmentation at 7T MRI. American Journal of Neuroradiology, 37 (6), 1050-57.
  15. Wisse, L.E.M., Butala, N., Das, S.R., Davatzikos, C., Dickerson, B.C., Vaishnavi, S.N., Yushkevich, P.A., & Wolk, D.A., for the Alzheimer’s Disease Neuroimaging Initiative (2015). Suspected non-AD pathology in Mild Cognitive Impairment. Neurobiology of Aging, 36 (12), 3152-62.
  16. Wisse, L.E.M., Reijmer, Y.D., Ter Telgte, A., Kuijf, H.J., Leemans, A., Luijten, P.R., Koek, H.L., Geerlings, M.I., & Biessels, G.J. (2015). Hippocampal disconnection in early Alzheimer’s disease: a 7 tesla MRI study. Journal of Alzheimer’s disease, 45 (4), 1247-1256.
  17. Yushkevich, P.A., Amaral, R.S., Augustinack, J.C., Bender, A.R., Bernstein, J.D., Boccardi, M., Bocchetta, M., Burggren, A.C., Carr, V.A., Chakravarty, M., Chetelat, G., Daugherty, A.M., Davachi, L., Ding, S.L., Ekstrom, A., Geerlings, M.I., Hassan, A., Huang, Y., Eugenio Iglesias, J., La Joie, R., Kerchner, G.A., LaRocque, K.F., Libby, L.A., Malykhin, N., Mueller, S.G., Olsen, R.K., Palombo, D.J., Parekh, M.B., Pluta, J.B., Preston, A.R., Pruessner, J.C., Ranganath, C., Raz, N., Schlichting, M.L., Schoemaker, D., Singh, S., Stark, C.E., Suthana, N., Tompary, A., Turowski, M.M., Van Leemput, K., Wagner, A.D., Wang, L., Winterburn, J.L., Wisse, L.E.M., Yassa, M.A., Zeineh, M.M.; for the Hippocampal Subfields Group (HSG) (2015). Quantitative comparison of 21 protocol for labeling hippocampal subfields and parahippocampal subregions in in vivo MRI: Towards a harmonized segmentation protocol. NeuroImage, 111, 526-541.
  18. Wisse, L.E.M., Biessels, G.J., Stegenga, B.T., Kooistra, M., Van der Veen, P.H., Zwanenburg, J.J.M., Van der Graaf, Y., & Geerlings, M.I. (2014). Major depressive episodes over the course of seven years and hippocampal subfield volumes at 7 tesla MRI: The PREDICT-MR study. Journal of Affective Disorder, 175, 1-7.
  19. Wisse, L.E.M., Biessels, G.J., & Geerlings, M.I. (2014). Critical appraisal of the hippocampal subfield segmentation package in FreeSurfer. Frontiers in Aging Neuroscience, 6, 261.
  20. Wisse, L.E.M., De Bresser, J., Geerlings, M.I., Reijmer, Y.D., Portegies, M.L.P., Brundel, M., Kappelle, L.J., Van der Graaf, Y., & Biessels, G.J. (2014). Global brain atrophy but not hippocampal atrophy is related to type 2 diabetes. Journal of Neurological Sciences, 344 (1-2), 32-36.
  21. Wisse, L.E.M., Biessels, G.J., Heringa, S.M., Kuijf, H.J., Koek, H.L., Luijten, P.R., & Geerlings, M.I. (2014). Hippocampal subfield volumes in Early Alzheimer disease and normal aging. Neurobiology of Aging, 35-9, 2039-2045.
  22. Wisse, L.E.M., Van Veluw, S.J., Kuijf, H.J., Spliet, W.G.M., Hendrikse, J., Luiten, P.R., Geerlings, M.I., & Biessels, G.J. (2013). Hippocampal T2 hyperintensities on 7Tesla MRI. NeuroImage Clinical, 3, 196-201.
  23. Wisse, L.E.M., Gerritsen, L., Zwanenburg, J.J.M., Kuijf, H.J., Luijten, P.R., Biessels, G.J., & Geerlings, M.I. (2012). Subfields of the hippocampal formation at 7T MRI: in vivo volumetric assessment. NeuroImage, 61 (4), 1043-1049.