First comparison of in vivo/ ex vivo MRI scans of the human hippocampus

In our recent publication in Cerebral Cortex we compared in vivo and ex vivo MRI scans of the human hippocampus and evaluated to ability to match information between the two modalities. We were able to validate several of the features used for manual subfield segmentation on in vivo MRI scans with ex vivo MRI, and showed subvoxel accuracy of the Automated Segmentation of Hippocampal Subfields (ASHS) of the stratum radiatum lacunosum moleculare (SRLM). Additionally, we were able to perform a preliminary evaluation of ASHS against histology-based segmentations in two subjects.

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