Automatic parcellation of neonate brains

 

In the absence of a neonatal template with cortical subregion labels, it can be extremely difficult to obtain cortical parcellation of new neonatal brain images automatically. We address this problem by utilizing adult templates with rich cortical annotation and a neonatal template with simple tissue labels. Theoretical feasibility is assured because of the preservation of brain putative cytoarchitectonic boundaries from birth to adulthood. We use large deformation registration to propagate neuroanatomical labels from adult to neonatal brain and perform multi-atlas labeling based on accurate prior-based tissue segmentation. We evaluate the repeatability of the labeling by cross-validation with training and testing data.

References:

  • J. Wu, M. Ashtari, L. M. Betancourt, N. L. Brodsky, J. Giannetta, J. Gee, H. Hurt, and B. Avants, “Cortical Parcellation for Neonatal Brains,” in IEEE 11th International Symposium on Biomedical Imaging, Beijing, China, 2014 (Oral presentation).
    [Bibtex]
    @CONFERENCE{WuISBI2014,
    author = {Jue Wu and Manzar Ashtari and Laura M. Betancourt and Nancy L. Brodsky
    and Joan Giannetta and James Gee and Hallam Hurt and Brian Avants},
    title = {{C}ortical {P}arcellation for {N}eonatal {B}rains},
    booktitle = {{IEEE} 11th {I}nternational {S}ymposium on {B}iomedical {I}maging},
    year = {2014 (Oral presentation)},
    address = {Beijing, China},
    month = {April},
    owner = {johnwoo},
    timestamp = {2014.02.11}
    }
  • J. Wu, M. Ashtari, L. M. Betancourt, N. L. Brodsky, J. Giannetta, J. Gee, H. Hurt, and B. Avants, “Cortical Parcellation for Neonatal Brains in MRI,” in Proc. 2014 Pediatric Academic Societies, Vancouver, Canada, 2014.
    [Bibtex]
    @CONFERENCE{WuPAS2014a,
    author = {Jue Wu and Manzar Ashtari and Laura M. Betancourt and Nancy L. Brodsky
    and Joan Giannetta and James Gee and Hallam Hurt and Brian Avants},
    title = {{C}ortical {P}arcellation for {N}eonatal {B}rains in {MRI}},
    booktitle = {{P}roc. 2014 {P}ediatric {A}cademic {S}ocieties, {V}ancouver, {C}anada},
    year = {2014},
    owner = {johnwoo},
    timestamp = {2014.02.12}
    }