Medial temporal lobe subregional morphometry using high resolution MRI in Alzheimer’s Disease


Recently published paper by Wolk et al. in Neurobiology of Aging examines the involvement of hippocampal subfields and medial temporal lobe (MTL) cortical subregions in different stages of Alzheimer’s disease (AD). The study used high-resolution T2-weighted MRI scans of the … Continue reading

Important milestone for the Penn ex vivo atlas of the human hippocampus formation

Labeling of hippocampal subfields in an ex vivo MRI scan on the basis of micro-anatomical features derived from histology.  Boundaries drawn in histology space are mapped into the MRI space after histology-MRI registration, and volumetric labeling of hippocampal subfields is performed in MRI space.

Daniel Adler’s MICCAI 2016 paper “Probabilistic atlas of the human hippocampus combining ex vivo MRI and histology” describes substantial progress on building a comprehensive atlas of the human hippocampus that combines ultra-high resolution ex vivo MRI and serial histological imaging. … Continue reading



SNAP is a software application used to segment structures in 3D medical images. It provides semi-automatic segmentation using active contour methods, as well as manual delineation and image navigation. In addition to these core functions, SNAP provides a number of … Continue reading